Vitamin D3 (2,500iu) (90-Day Supply)
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Vitamin D3
(90-Day Supply)

#270 Veggie Caps (90-Day Supply)

Price: $30.15
Product ID : CBVITD
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In the traditional use of terms in allopathic medicine, vitamin D deficiency was defined as a level low enough to cause rickets or osteomalacia, two very serious bone diseases.  Over the past 13 years, the discovery of vitamin D receptors in multiple organs and tissues throughout the human body prompted a large number of biochemical and clinical studies on vitamin D’s role in disease prevention.  As a result, emerging data today point to a much broader role for vitamin D in human health.  Current consensus among authorities on vitamin D establish 3 categories of vitamin D status based on serum level of 25-hydroxy vitamin D:

  • Deficient: Less than 10ng/ml
  • Insufficient: Less than 20ng/ml
  • Optimal: Above 20ng/ml

These values are largely based on the relationship between low levels of vitamin D and the prevalence of rickets and osteomalacia.  Many studies, however, point to the possibility of greater protection from age-related disease with higher vitamin D levels.  These data, coupled with the recent alarming discovery that many Americans are deficient in vitamin D has prompted us at the Leonardi Institute and many other nutritional experts to recommend doses of at least 1,000 units per day.  For those who follow their blood level of 25-hydroxy vitamin D, doses from 2500iu up to 10,000iu daily are often needed to achieve levels of 50 to 70ng/ml, the level we recommend for optimal health. Below is some information on published studies that support levels of vitamin D above the "insufficient" threshold.


Osteoporosis is severe bone loss. Risk increases with age and results in 325,000 hip fractures per year in the U.S. alone.  Such fractures carry a 20% mortality within 6 months, resulting in 65,000 U.S. fatalities per year.  Low levels of vitamin D cause parathyroid hormone (PTH) levels to rise, moving calcium out of our bones.  It’s been well documented that low vitamin D and high PTH levels increase fracture risk.1

Cancer Risk:

A randomized, double-blind, placebo-controlled study of 1179 women over age 55 living in Nebraska was carried out by investigators at Creighton University in Omaha and published in the Journal of Clinical Nutrition.2  Those who took 1,400-1,500mg of calcium daily along with 1,100 iu of vitamin D had 60% fewer cancers over the next 4 years than women on placebo.  To reduce the influence of cancers that were likely to be already present (but not diagnosed) at the study onset, they then excluded cancers diagnosed in the first year of the study.  In that calculation, the calcium and D group had 73% fewer cancers.  When subjected to the most strict statistical analysis (multiple logistic regression), the serum level of 25-hydroxy vitamin D was found to be an independent predictor of cancer risk.  The serum level achieved in this study to provide the reduced cancer risk was 38.5ng/ml.  As you can see, this is well above the level considered optimal among authorities who are primarily focused on disease as opposed to disease risk.

Diabetes Risk:

Few doctors would associate vitamin D status with diabetes risk.  Two studies published in 2011 provide convincing evidence of just such a connection.  Caucasians with 25-hydroxy vitamin D levels above 32ng/ml were shown to have half the risk of diabetes compared to those with levels below 15ng/ml.3  And vitamin D levels correlate inversely with insulin resistance, the cause of type 2 diabetes (the lower the vitamin D level, the greater the insulin resistance).4

Muscle performance (both skeletal and cardiac):

There is a direct correlation with muscle strength and vitamin D status in older men and women.5  And this relationship extends to heart muscle as well.  Indicators for the severity of congestive heart failure increase as vitamin D levels decrease.6

Immune status and infections:

There is good evidence that our vitamin D status effects our immune system and the ability of our white blood cells to fight infections.7,8

Autoimmune Disease:

Vitamin D helps to control the release of inflammatory chemicals (cytokines) involved in the immune system attack upon “self” in autoimmune disease.9,10  Epidemiologic studies support the relationship of low vitamin D status with Multiple Sclerosis,11,12 inflammatory bowel diseases13,14 and rheumatoid arthritis.15,16

Degenerative Arthritis (Osteoarthritis):

In the general population, the progression of osteoarthritis was shown to be faster in those with 25-hydroxy vitamin D levels below 34ng/ml (part of the Framingham Study).17


People taking over 2,000 iu of vitamin D per day should periodically measure serum 25-hydroxy vitamin D with a goal of keeping it above 32 and below 70ng/ml.  Be sure to distinguish between these units (ng/ml) and another designation (nMol/L).  To convert nMol/L to ng/ml, divide the value for nMol/L by 2.5.

1 Calcif Tissue Int. 2011 Mar;88(3):238-45. Epub 2010 Dec 23
Am J Clin Nutr. 2007 Jun;85(6):1586-91
Br J Nutr. 2011 May 17:1-6
J Nutr. 2011 Jun 22
Arch Phys Med Rehabil. 1999 Jan;80(1):54-8
6  J Am Coll Cardiol. 2003 Jan 1;41(1):105-12
J Clin Endocrinol Metab. 1983 Dec;57(6):1308-10
Calcif Tissue Int. 2000 Jun;66(6):476-8
J Clin Invest. 1998 Jan 1;101(1):252-62
10Immunol Lett. 1991 May;28(2):115-20
11N Neurologie.1987 In Lehrbuch der Inneren Medizin, pp.1065-1067
12Neuroepidemiology. 1992;11(4-6):244-54
13Scand J Gastroenterol. 2002 Feb;37(2):192-9
14Aliment Pharmacol Ther. 2002 Nov;16(11):1895-902
15Osteoporos Int. 2000;11(9):739-44
16Scand J Rheumatol. 1993;22(4):172-7
17Ann Intern Med. 1996 Sep 1;125(5):353-9

Supplement Facts:
Serving Size: 1 Capsule
Servings per container: 270
Vitamin D3 (as Cholecalciferol) (2,500iu)
Other Ingredients: Rice Flour, Cellulose (capsule), Magnesium Stearate.
Recommended Dose: One to three capsules per day with food, or as directed by your practitioner to keep 250H Vitamin D level between 50 and 100ng/mL.

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