TMG 700mg (90-Day Supply)
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TMG 700mg
(90-Day Supply)

#360 Veggie Caps (90-Day Supply)

Price: $67.75
Product ID : CBTMG
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As the name suggests, trimethylglycine (TMG) consists of a glycine molecule adorned by three methyl groups.  TMG is also referred to as betaine.  TMG is produced naturally within the body and consumed in significant amounts through the diet (1 to 2.5 grams per day).  This nutrient can be found in beets, spinach, liver, eggs and seafood.1

Perhaps the most well recognized role of TMG in the body, however, is its contribution to reducing homocysteine levels and generating critical downstream products of homocysteine metabolism.  Homocysteine is converted to methionine and then s-adenosylmethionine (SAMe) by enzymatic methylation.  TMG can serve as a methyl donor for this pathway.2  The accumulation of homocysteine is clearly associated with a higher risk of dementia and possibly cardiovascular disease while a deficiency in methionine and SAMe may be associated with fatty liver disease.3,4  A recent study indicated that subjects with a higher intake of TMG had 10% lower levels of serum homocysteine and 19% lower levels of CRP (c-reactive protein; an inflammatory marker) than subjects with the lowest intake.5

TMG has other physiological roles. Perhaps its simplest role is to act osmotically in retaining cellular fluid and, thus, improve the physiological tolerance of dehydration.6,7  TMG also appears to play a role in hepatic fat metabolism (helping to control fatty liver), creatine synthesis and muscle function, and gene expression in general.8,9  There is also the suggestion that TMG can help reduce body fat in animal models.10

Each capsule of Cycle-Breakers TMG contains 700mg of TMG.  Typical doses of supplemental TMG range from 1,000mg to 6,000mg per day, depending upon the indication for use as well as individual results as revealed through medical monitoring.

Am J Clin Nutr 2004;80:539-49
Arch Intern Med. 2000 Sep 11;160(16):2546-7
Am J Clin Nutr 2004;80:539-49
Am J Gastroenterol 2001;96:2711-7
Am J Clin Nutr. 2008 Feb;87(2):424-30
Am J Clin Nutr 2004;80:539-49
Br J Clin Pharmacol. 2003 Jan;55(1):6-13
Am J Gastroenterol 2001;96:2711-7.
Am J Clin Nutr 2004;80:539-49
10Altern Med Rev 2003;8:193-6

Supplement Facts:
Serving Size: 1 Capsule
Servings per container: 360
Trimethylglycine (700mg)
Other Ingredients: Cellulose (capsule), Magnesium Stearate, Maltodextrin.
Recommended Dose: One to three capsules, twice a day with food, or as directed by your practitioner to keep homocysteine level below 7 uMOL/L.

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