Policosanol 20mg (90-Day Supply)
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Policosanol 20mg
(90-Day Supply)

#90 Veggie Caps (90-Day Supply)

Price: $31.15
Product ID : CBPOLI
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Description

Policosanol is the name for a complex mixture of alcohol compounds (mostly octacosanol) typically derived from sugar cane wax.  Policosanol has been evaluated for its potential to improve cholesterol (lipoprotein) levels, reduce the risk of cardiovascular disease, reduce claudication (pain from arterial congestion) and improve cognitive performance.

Policosanol is attractive as a lipid lowering therapy due to its good safety profile and low cost.  Initial studies conducted in Cuba by a policosanol producer revealed excellent efficacy.  Over six months, policosanol achieved a 31.2% reduction in LDL cholesterol, a 23.0% in total cholesterol, and an 8.7% increase in HDL cholesterol.  Several follow up studies also produced impressive results including one lasting two years and showing a 29.5% reduction in LDL cholesterol, a 21.9% reduction in total cholesterol, a 16.9% reduction in triglycerides, and a 12.4% increase in HDL cholesterol.

Several studies outside of Cuba also demonstrated great results including an Argentinean study showing a 26.7% reduction in LDL cholesterol, a 19.5% reduction in total cholesterol, and a 7.4% increase in HDL cholesterol.  However, other well done studies have found no benefit from policosanol over placebo in regard to cholesterol levels.  One possible explanation for this discrepancy can be found in the length of the studies.  While there is some overlap between the length of positive and negative studies, positive studies were generally longer (8 weeks to 2 years) while negative studies were generally shorter (6 weeks to 10 weeks). This suggests that policosanol may be most efficacious with longer treatment periods.  Differences in policosanol quality and composition may also underlie some of this discrepancy.  Hopefully ongoing research will elucidate these details more clearly in the near future.  Overall, the cumulative results from numerous studies evaluating the effect of policosanol on cholesterol are quite positive and comparable to older statin drugs, as reviewed in the American Heart Journal in 2002.

Several studies suggest that policosanol may also improve intermittent claudication, a painful condition which occurs during walking due to an impaired arterial supply to the legs.  This pain is analogous to the chest pain (angina pectoris), which occurs when the coronary arteries are impaired.  Possibly through its ability to reduce platelet clumping, policosanol improved the symptoms and functional limitations of intermittent claudication more effectively than aspirin and equivalently to an antiplatelet drug (ticlodipine) in randomized and blinded studies.

Finally, policosanol may improve cognitive function in the domain of reaction time as demonstrated in a population of students and karate athletes.

Most of these positive studies for cholesterol lowering, claudication therapy, and enhancing reaction time used doses ranging from 10mg to 20mg daily to achieve maximal results.

References:
Int J Clin Pharmacol Res. 1994;14(1):27-33
Asia Pac J Clin Nutr. 2004;13 Suppl:S1-176
Int J Clin Pharmacol Res. 2001;21(1):31-41
Am J Clin Nutr. 2006 Dec;84(6):1543-8
JAMA. 2006 May 17;295(19):2262-9
Complement Ther Med. 2008 Apr;16(2):61-5. Epub 2008 Jan 18
Am Heart J. 2002 Feb;143(2):356-65
Angiology. 2008 Jun-Jul;59(3):269-77. Epub 2008 Apr 2
Angiology. 2004 Jul-Aug;55(4):361-71
Neuropsychobiology. 2000;41(3):158-65
J Am Coll Nutr. 2009 Aug;28 Suppl:473S-481S

Supplement Facts:
Serving Size: 1 Capsule
Servings per container: 90
Ingredients:
Policosanol (20mg)
Other Ingredients: Cellulose (capsule), Rice Flour, Magnesium Stearate, Silica.
Recommended Dose: One capsule per day with evening meal, or as directed by your practitioner.

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