Melatonin 1mg (90-Day Supply)
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Melatonin 1mg
(90-Day Supply)

#90 Veggie Caps (90-Day Supply)

Price: $15.45
Product ID : CBMEL1
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Description

Melatonin is a hormone produced by the pineal gland during darkness.  It is commonly known as the hormone that promotes deep sleep and regulates circadian rhythm (day/night, sleep/awake cycle).  Indeed, melatonin and melatonin agonist drugs are of great interest in insomnia and sleep disorder research at the moment.  Studies have shown that melatonin may reduce the time it takes to fall asleep.1  The European Medicines Agency has approved a slow release melatonin for the short term treatment of primary insomnia in patients who are aged 55 or above.2

But melatonin appears to possess much broader activity.  Studies have shown that it also acts as an antioxidant and immune stimulant and data suggests that low melatonin levels due to inadequate sleep may be related to a greater risk of cancer.  Some researchers have suggested that melatonin may enhance chemotherapy in the treatment of prostate cancer and other solid tumors.3,4  Persons who are totally blind have higher melatonin levels because melatonin production is suppressed by light perception and, of course, people who are totally blind cannot perceive light.  Associated with this higher level of melatonin is a 31% reduced incidence of all cancers in persons totally blind.5  In vitro (cell culture studies) melatonin has demonstrated activity against breast6,7,8, prostate9, neuroblastoma10 (brain) and melanoma11 (skin) cancers.  Additionally, new research is also demonstrating a link among sleep deficiency, cognitive impairment and Alzheimer’s disease (AD).  The mechanisms behind these associations are multiple, but melatonin deficiency is probably one of them.

Here are the findings of some studies relating melatonin to AD specifically:

  1. Melatonin has been shown to prevent cell damage induced by beta amyloid in the hippocampus of the brain.  The hippocampus is the primary memory region of the brain and the area most affected by AD.  Melatonin also combats inflammation and the phosphorylation of tau protein.12

  2. Mice bred to develop AD were fed aluminum to increase brain damage via oxidative stress.  Mice that were also given melatonin exhibited greatly reduced oxidation in the brain in response to the aluminum.13

  3. Melatonin can reduce oxidative damage within the mitochondria (energy factories) of brain cells and rescue the brain cells from self-destruction.14  This self-destruction, or apoptosis, of brain cells is a common final pathway in a number of neurodegenerative conditions.15

  4. The anti-apoptotic effects of melatonin are not just mediated through its antioxidant properties but also through its influence on gene products called sirtuins, which tend to improve the function and longevity of cells.16


References:
1 Sleep 1995 Sep;18(7):598-603
2 Int J Neurosci. 2009;119(6):821-46
3 Eur Urol 1997;31:178-81
4 Eur J Cancer 1999;35:1688-92
5 Epidemiology. 1998 Sep;9(5):490-4
6 Endocr Relat Cancer. 2003 Jun;10(2):153-9
7 J Pineal Res. 2002 Mar;32(2):90-6
8 J Pineal Res. 2000 Oct;29(3):166-71
9 Prostate. 2004 Sep 17
10Neurosci Lett. 1996 Sep 27;216(2):113-6
11 Melanoma Res. 2001 Apr;11(2):197-201
12J Pineal Res. 2010 Apr;48(3):230-8. Epub 2010 Jan 28
13Biol Trace Elem Res. 2010 Jun;135(1-3):220-32. Epub 2009 Aug 13
14J Pineal Res. 2004 Aug;37(1):55-70
15CNS Neurosci Ther. 2009 Winter;15(4):345-57. Epub 2009 Oct 10
16J Pineal Res. 2009 Oct;47(3):228-37. Epub 2009 Jul 23

Supplement Facts:
Serving Size: 1 capsule
Servings per container: 90
Ingredients:
Melatonin (1mg)
Other Ingredients: Cellulose (capsule), Parsley Leaf, Magnesium Stearate, Silica.
Recommended Dose: One capsule at bedtime or as directed by your practitioner.

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