Mag-Chelate 200mg (90-Day Supply)
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Mag-Chelate 200mg
(90-Day Supply)

#180 Veggie Caps (90-Day Supply)

Price: $41.00
Product ID : CBMAG
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Description

Magnesium is one of the most plentiful ions (i.e. electrolytes) in the body.  It is essential for normal cell function, including nerve conduction and muscle contraction, and is involved in more than 300 enzyme systems.1  Magnesium is clearly a critical nutrient but magnesium deficiency is fairly common in the US.2  Low intakes, impaired absorption, or low serum levels of this critical nutrient have been associated with a number of disorders, including osteoporosis, hypertension, vascular disease, stroke, migraine headaches, depression, premenstrual syndrome (PMS), constipation, diabetes, and sudden cardiac death.3,4,5,6,7,8,9  Let’s take a closer look at some of these associations.

Osteoporosis is a condition of abnormally low bone mineral density.  Bone mineral density is determined by numerous factors including the availability of key minerals like calcium and magnesium as well as the activity of cells called osteoblasts (which build bone) and osteoclasts (which break down bone).  Low levels of magnesium are associated with reduced osteoblast activity and increased osteoclast activity. T he result is a loss of bone mineral density and bone thickness.10  Efforts to increase dietary magnesium intake have been shown to improve bone mineral density in post menopausal women11.  Further, supplementation with 250-750mg of magnesium daily has been shown to improve bone mineral density over one and two years.12

There is abundant evidence to suggest that magnesium intake is related to the risk for type II diabetes mellitus and insulin resistance.  Higher intakes of magnesium (from diet and supplementation) have been associated with an 11-34% reduction in type II diabetes and lower serum insulin levels (an indication of better insulin sensitivity).13,14,15  Magnesium supplementation and serum levels have also been shown to affect the related condition of metabolic syndrome (insulin resistance, high blood pressure, dyslipidemia, and abdominal obesity).16,17

Migraine headaches are a common and debilitating problem.  The physiology of migraines is complex, but a central mechanism involves the constriction of cerebral arteries. Low levels of magnesium may contribute to this arterial constriction and increase the risk of migraine headaches.18  It is not surprising then that magnesium supplementation has been shown to prevent migraines.19  In one study, supplementation with 600mg of magnesium daily for 12 weeks reduced migraine attacks by 41.6%.20

Magnesium may produce powerful effects on mood disorders.  A recent review article discussed the success in improving treatment resistant depression with magnesium and hypothesized that "magnesium treatment will be found beneficial for nearly all depressives.21  Premenstrual syndrome (PMS) and premenstrual dyphoric disorder (PMDD) are clusters of unpleasant symptoms which occur in the later half of the menstrual cycle, just before menstruation.  A prominent feature of both conditions is a negative mood state (depression, irritability, emotional sensitivity, etc.).  Studies suggest that low magnesium levels may contribute to these conditions and magnesium supplementation may be helpful in alleviating certain symptoms.  For example, one study demonstrated that 1080mg of magnesium taken each day starting on day 15 of the menstrual cycle and taken until menstruation begins, can significantly reduce premenstrual negative mood states.22

Magnesium has been used as a laxative for some time. It works both as an osmotic agent, meaning it pulls water into the intestines, and by stimulating gastric and intestinal motility.23 This action of magnesium can be an unwanted side effect when used for other reasons, or a desirable effect in the setting of constipation.

Sudden cardiac death is just that, sudden death from a heart problem.  A recent study of 88,375 healthy women (nurses) demonstrated that the risk of sudden cardiac death decreased 41% for every 0.25mg/dl increase in serum magnesium.24  This suggests that it is ideal to have serum magnesium levels on the upper end of the 1.6-2.6 mg/dl normal distribution.

Perhaps the most surprising benefit from maintaining higher serum magnesium levels is a reduced risk of certain cancers.  For example, women with the highest intake of magnesium had a 34% reduction in colon cancer incidence and a 55% reduction in rectal cancer incidence.25  Likewise, higher intake of magnesium through water sources has been associated with reductions in deaths from liver, ovarian, and esophageal cancers.26,27,28

Oral magnesium supplements come in many forms.  The most effectively absorbed forms of magnesium appear to be magnesium amino acid chelate (ACC) and magnesium citrate.29,30


References:
1 J Bone Miner Res. 1998 Apr;13(4):749-58
2 J Nutr. 2003 Sep;133(9):2879-82
3 Am J Clin Nutr. 2002;75:65-71
4 J Neurosci Lett 1997;230:37-40
5 J Nutr. 2003 Sep;133(9):2879-82
6 Med Hypotheses. 2010 Apr;74(4):649-60
7 Eur J Intern Med. 2004;15:97-107
8 Headache 2002;42:114-9
9 Am J Clin Nutr. 2011 Feb;93(2):253-60.
10Eur J Intern Med. 2004;15:97-107
11J Reprod Med. 1990 May;35(5):503-7
12Magnes Res. 1993 Jun;6(2):155-63
13Diabetes Care. 2004 Jan;27(1):59-65
14Diabetes Care. 2004 Jan;27(1):134-40
15J Am Coll Nutr. 2003 Dec;22(6):533-8
16J Am Coll Nutr. 2004 Oct;23(5):506S-509S
17Diabetes Care. 2005 Jun;28(6):1438-44
18Headache 2002;42:114-9
19Headache 1991 May;31(5):298-301
20Cephalalgia. 1996 Jun;16(4):257-63
21Med Hypotheses. 2010 Apr;74(4):649-60
22Obstet Gynecol. 1991 Aug;78(2):177-81
23South Med J 1999;92:1040-7
24Am J Clin Nutr. 2011 Feb;93(2):253-60.
25JAMA. 2005 Jan 5;293(1):86-9
26Magnes Res. 2004 Mar;17(1):46-52
27Magnes Res. 2004 Mar;17(1):28-34
28Magnes Res. 2002 Dec;15(3-4):215-22
29Magnes Res. 2003 Sep;16(3):183-91
30Magnes Res. 2001 Dec;14(4):257-62

Supplement Facts:
Serving Size: 1 Capsule
Servings per container: 180
Ingredients:
Magnesium (as Magnesium AAC) (200mg)
Other Ingredients: Cellulose (capsule), Magnesium Stearate, Silica.
Recommended Dose: One to four capsules per day on an empty stomach for best absorption. Reduce dose if experiencing diarrhea.  If you have kidney disease, consult your doctor before using this product.

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