DIM 250mg (90-Day Supply)
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DIM 250mg
(90-Day Supply)

#90 Veggie Caps (90-Day Supply)

Price: $53.45
Product ID : CBDIM
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Brassica vegetables like broccoli, cauliflower, kale, Brussels sprouts, cabbage and bok choy contain compounds called glucosinolates. They also contain an enzyme called myrosinase. Chewing these remarkable vegetables releases the myrosinase, which then converts the glucosinolates into cancer-preventive, cancer-inhibiting compounds called indoles and isothiocyanates. Lots of syllables here but the bottom line is this: when you eat this class of vegetables, you get cancer-inhibiting nutrients.

One problem with relying on the vegetables for these cancer-inhibiting nutrients is that one would have to eat quite a large quantity every day to achieve a substantial effect. Another problem is that cooking the vegetables (heat) inactivates the myrosinase enzyme that provides the benefit, although some benefit is still available from myrosinase provided by our intestinal bacteria. So eating these vegetables raw is the ideal method of consumption. Most people don’t enjoy raw brassica vegetables nearly enough to consume a cancer-inhibiting dose day in and day out.

One of these important nutrients is diindolylmethane or DIM for short. DIM has been widely tested in biochemical, animal and human clinical trials since 1998, and is available as a nutritional supplement.

To provide you with information on the benefit of DIM, below are a few comments about, and links to, published clinical trials on this important compound. The FDA allows us only to say that DIM may help to maintain optimal health of breast, liver, prostate, bladder, pancreas, colon, lungs and thyroid.

However, we can certainly discuss results of individual clinical trials on DIM and refer you to the actual published study on the Pub Med website of the United States National Library of Medicine. A link to the published study is provided at the end of each study discussion below. These are only a few of the many studies published on DIM. Feel free to use the PubMed website to find many more.

This first study is entitled: Broccoli-derived phytochemicals indole-3-carbinol and 3,3'-diindolylmethane (DIM) exerts concentration-dependent pleiotropic effects on prostate cancer cells: Comparison with other cancer preventive phytochemicals. Published in Molecular Carcinogenesis, it details how many of the biochemical pathways to cancer are affected by DIM and Indole-3-Carbinol. After examining each of these molecular pathways, the authors end the abstract with this statement: "Based on our results, a model for cancer protective effects of DIM and I3C was proposed." Click Here

In another study, DIM was investigated as an inhibitor of prostate cancer using a mouse model. We’ll just quote the authors on this one: "3,3'-Diindolylmethane (DIM) is a major in vivo derivative of indole-3-carbinol, which is present in cruciferous vegetables and has been reported to possess anti-carcinogenic properties. In the present study, we examined whether DIM inhibits the development of prostate cancer using the transgenic adenocarcinoma mouse prostate (TRAMP) model. "These results indicate that DIM inhibits prostate carcinogenesis via induction of apoptosis and inhibition of cell cycle progression." Click Here

Here’s one regarding breast cancer. Chemicals called transcription factors effect the manufacture of proteins in our body that can affect disease risk, including cancer risk. One such factor that promotes breast cancer is called FoxM1. The following is a quote from the authors of the study, the whole of which you can read by clicking on the link that follows: "Since elevated expression of FoxM1 has been observed in human breast cancers, FoxM1 has attracted much attention in recent years as a potential target for the prevention and/or therapeutic intervention in breast cancer." Here we report for the first time that 3,3'-diindolylmethane (DIM), a non-toxic dietary chemopreventive agent could effectively down-regulate FoxM1 in various breast cancer cell lines." Click Here

Another study demonstrated that DIM inhibited the spread of thyroid cancer by helping to prevent their "adhesion, migration and invasion" and thereby inhibiting their ability to spread. Click Here

Human estrogen is broken down in the body into many byproducts. One of these that is carcinogenic is 16-alpha-hydroxy estrogen. This study, one of many, shows how DIM alters the breakdown of estrogen to reduce the 16-alpha-hydroxy estrogen in favor of the benign 2-hydroxy estrogen. Here is a quote from the authors regarding the effect of DIM in their study: "There was an increase in the ratio of 2-hydroxyestrones (C-2) to 16α-hydroxyestrone (C-16)... Click Here

The link below is to a review article on the topic of epigenetics, the science of gene expression. Our genes provide a blueprint for the construction and operation of our body. What few people realize, however, is that our genes can be turned on and off repeatedly throughout the day by characteristics in their cellular environment. Those characteristics are influenced by our lifestyle including how much we exercise, what we eat and what supplements we take. Epigenetics is primarily why eating healthfully, exercising and taking supplements help to keep us healthy. This article reviews unhealthy epigenetic mechanisms by which cancer develops and examines many compounds, including DIM, that can alter these mechanisms. Here is a quote from the authors: "The present review will give a comprehensive overview of the current literature on chemopreventive agents and their influence on major epigenetic mechanisms..." If you click on the link, you’ll see they examine evidence on a long list of plant compounds and you’ll see DIM about half way down the list. But please read the first few sentences. Then scan the nearly endless biochemical terms just to get a TINY sense of the enormous biochemical universe and its complexities. Next time you meet a biochemist, kiss his or her ring. These are the brilliant and dedicated scientists that perform this amazing research to help us bring you the most effective products we can find. Click Here

Scientists often use plant compounds that exhibit anti-cancer activities for drug development. If they alter the compound slightly in the laboratory, they hope to synthesize a compound with equal or stronger anti-cancer effects that they can patent or use to collaborate with a drug company. This opens the door to the possibility of making billions of dollars with a patented, FDA-approved drug. In this study, DIM was used as a base molecule to derive compounds called C-DIMs that exhibited substantial anti-cancer effects on human mouth cancer cells. Click Here

We can’t tell you with certainty that taking DIM can prevent any cancer. What we can tell you truthfully, is that after reading the above studies and many more, we, the physicians of the Leonardi Institute and our families eat lots of brassica vegetables and take DIM every day.

Supplement Facts:
Serving Size: 1 Capsule
Servings per container: 90
DIM (diindolylmethane) (250mg)
Other Ingredients: Vegetable Cellulose (capsule), Maltodextrin, Magnesium Stearate, Silicon Dioxide.
Recommended Dose: One capsule per day with a meal, or as directed by your practitioner.

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