Brain Synergy (90-Day Supply)
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Brain Synergy
(90-Day Supply)

#180 Veggie Caps (90-Day Supply)

Price: $248.15
Product ID : CBBS
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Most of today’s drugs for Alzheimer’s disease merely attempt to squeeze more neurotransmitter from the remaining healthy brain cells. While we can’t revive dead neurons, science shows us that we can help keep our brain’s cells healthy despite the destructive forces of glycation, oxidative stress and inflammation. The purpose of Brain Synergy™ is to do just that. Clinical studies on delayed progression and even short-term improvement in Alzheimer’s disease patients and enhancement of cognitive performance in normal subjects gave us crucial insight while formulating the components of Brain Synergy™.

While Brain Synergy™ by itself offers tremendous benefit, for optimal results we recommend you use Brain Synergy™ along with Epigenetic Symphony™ and our CoQSol formula. This is consistent with our Designed to Combine protocol that prevents wasteful and potentially dangerous duplication of ingredients when combining formulas.

Oxidative Stress is one of the most obvious and important causes of neurodegenerative disease. Alzheimer’s brains, on autopsy, contain lower levels of antioxidants and higher levels of byproducts of free radical production as well as higher levels of the pro-oxidant reactive metals Fe++ and Cu++. Parkinson’s disease shares many of the etiologic features of Alzheimer’s, particularly in the arena of free radical production. Likewise, glycation and inflammation play a significant role in the brain cell loss of Alzheimer’s disease. This is why it’s so important to use Epigenetic Symphony™ (ES) as a cornerstone formula along with Brain Synergy™. ES serves as a potent multi-vitamin, multi-mineral and antioxidant formula, while also providing a number of specific ingredients critical to reducing oxidative stress, glycation and inflammation. Once ES is in place in your program, Brain Synergy™ is a critical adjunct. Here are some key points:

  • Phospholipids are the major components of neuronal membranes. Unlike phosphatidyl choline (PC), for which two large review articles published by the Cochrane Database found no benefit, phosphatidyl serine (PS) and glycerophosphocholine (GPC) appear quite promising and the evidence from published clinical trials follows below. These two important phospholipids are major components of Brain Synergy™. We’ve not found another formula anywhere with 1,000mg of GPC per daily serving. Note: GPC is also called choline alfoscerate (CA). These are two different names for the identical compound.

The evidence for phosphatidyl serine (PS):

In a placebo-controlled study of 51 patients with probable Alzheimer’s Disease (AD), phosphatidyl serine at 300mg daily resulted in improvement over placebo in several cognitive measures. In 12 weeks, those on PS improved on several cognitive measures compared to the placebo group.1

In a double-blind, placebo-controlled study of Parkinson’s patients who also had senile dementia of Alzheimer’s type, PS resulted in improvement in the Sandoz Clinical Assessment Geriatric Scale.2

A Scandinavian randomized, bouble-blind placebo controlled trial of PS for senile dementia demonstrated cognitive improvement compared to placebo in two distinct rating scales in just six weeks.3

An Italian study published in Aging (Milano) compared PS vs. placebo in 494 elderly demented patients. Using Plutchik Geriatric Rating Scale and the Buschke Selective Reminding Test, the PS group improved significantly relative to the placebo group over the six months.4

A placebo-controlled crossover study is done in three phases. The first compares a treatment to placebo. The second phase is called a "washout" wherein treatment is stopped long enough to allow the medicine or supplement to be completely eliminated from the body. The third phase also compares treatment to placebo, but the groups are switched (crossed over) so that the original treatment group is now the placebo group and vice versa. This eliminates the possibility that any improvement is due to overlooked characteristics peculiar to the group rather than the intervention. Such a study was done at the U of Munich using PS 300mg daily vs. placebo in 33 demented patients. Significantly more patients in the PS group improved relative to the placebo group in Clinical Global Improvement Ratings and this effect was duplicated in the 2nd (crossover) part of the trial.5

Here’s the evidence for glycerophosphocholine (glycerophosphorylcholine, choline alfoscerate):

In a multicenter, double-blind, randomized placebo-controlled clinical trial, patients with mild to moderate Alzheimer’s who received GPC daily for 6 months improved in a key test of Alzheimer’s called ADAS-cog. Over six months, the GPC group improved by 3.2 points while the placebo group deteriorated by 2.9 points, a total and very significant difference of 6.1 points.6

A multicentre, randomised, controlled study of GPC on 126 patients with probable dementia of the Alzheimer’s type by the University of Perugia, Italy showed significant improvements in most neuropsychological parameters.7

Three published studies also show benefit of GPC in treating memory loss due to stroke or TIA (mini-stroke).8,9,10

1 Psychopharmacol Bull. 1992;28(1):61-6
2 Prog Clin Biol Res. 1989;317:1235-46
3 Acta Neurol Scand. 1986 Feb;73(2):136-40
4 Aging (Milano). 1993 Apr;5(2):123-33
5 Eur Neuropsychopharmacol. 1992 Jun;2(2):149-55
6 Clin Ther. 2003 Jan;25(1):178-93
7 Drugs Aging. 1993 Mar-Apr;3(2):159-64. Related Articles
8 Mech Ageing Dev. 2001 Nov;122(16):2041-55
9 J Int Med Res. 1991 Jul-Aug;19(4):330-41
10Ann N Y Acad Sci. 1994 Jun 30;717:253-69

Supplement Facts:
Serving Size: 1 Capsule
Servings per container: 180
alpha-Glycerophosphorylcholine (500mg)
Phosphatidylserine (150mg)
Other Ingredients:  Cellulose (capsule), Silica, Magnesium Stearate, di-Calcium Phosphate.
Recommended Dose:  Two capsules per day with food, preferrably divided as one with breakfast and one with dinner, or as directed by your practitioner.

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